Background: Information on acute kidney injury (AKI) in elderly hospitalized patients is limited. This study aims to\nassess the incidence, risk factors and outcomes of AKI in elderly Chinese patients.\nMethod: The Epidemiology of AKI in Chinese Hospitalized adults (EACH) study is a multicenter, retrospective cohort\nstudy conducted in nine regional central hospitals across China. Patients aged more than 65 years were selected\nfrom the EACH study for this analysis. A novel approach with adjustment for frequency of serum creatinine was\nused to estimate the incidence of AKI in elderly patients. In-hospital outcomes, including mortality, renal recovery,\nlength of stay and daily cost of elderly patients, were analyzed and compared with outcomes in younger patients.\nResults: Of 144,232 adult patients in the EACH study, 42,737 (29.63 %) patients were 65 years or older, including 9773\nvery elderly patients (ââ?°Â¥80 years old). The incidence of AKI was 15.44 % in patients 65ââ?¬â??79 years old (community-acquired\n(CA) AKI of 3.89 % and hospital-acquired (HA) AKI of 11.55 %) and 22.22 % in the very elderly group (CA-AKI of 6.58 %\nand HA-AKI of 15.64 %). The mortality rate of AKI was 10.3 % in patients aged from 65 to 80 and 19.6 % in patients older\nthan 80 years. AKI incidence, in-hospital mortality, percentage of patients requiring dialysis and percentage without renal\nrecovery were higher in elderly patients than in younger patients.\nConclusion: The incidence of AKI in elderly Chinese hospitalized patients is high, which becomes a substantial\nburden on medical care in China.
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